| 申美霞,王少华,熊淑英,王兴勇.白藜芦醇甙对大鼠急性肺损伤模型的保护机制.[J].中南医学科学杂志.,2006,(1):18-20. |
| 白藜芦醇甙对大鼠急性肺损伤模型的保护机制 |
| Protective Effects of Polydatin on Injury Following Endotoxic Shock in Rats |
| 投稿时间：2005-10-10 |
| DOI： |
| 中文关键词: 休克 内毒素 肺损伤 白藜芦醇甙 |
| 英文关键词:shock endotoxin lung injury Polydatin |
| 基金项目:广东省深圳市福田区科技局立项项目 |
| 申美霞 王少华 熊淑英 王兴勇 |
| [1]深圳市福田区妇幼保健院儿科,广东深圳518026 [2]重庆医科大学儿科学院,广东深圳518026 |
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| 中文摘要: |
| 目的研究白藜芦醇甙（PD）对休克大鼠肺损伤的干预机制.方法将休克性肺损伤大鼠随机分为4组：单纯手术组、内毒素休克组、PD预防组和PD治疗组,检测肺系数、肺组织肺通透指数（LPI）、肺泡灌洗液（BALF）中蛋白含量及磷脂酶A2（PLA2）活性,观察肺组织病理切片.结果 PD预防组和治疗组中LPI、BALF中蛋白含量、PLA2较对照组明显降低;PD可明显减轻内毒素休克性肺损伤的程度.结论白藜芦醇甙对大鼠内毒素休克性肺损伤具有保护作用,且预防性用药效果更佳. |
| 英文摘要: |
| Objective To investigate the interfered effects of Polydatin on endotoxic shock-induced lung injury in rats. Methods The endotoxic shock model of rats were randomly divided into 4 groups as sham operation group,endotoxic shock group,Polydatin treatment group and Polydatin pretreatment group.The lung coefficient(LC),the lung penetrated index(LPI),protein content of BALF and the activity of PLA_2 were determined.Results The activity of PLA_2,LC,LPI and protein content of BALF in Polydatin treatment groups were lower than those in sham operation groups.The degree of endotoxic shock-induced lung injury can be eased by Polydatin.Conclusion The protection effect of Polydatin on acute lung injury is remarkable,and the prophylactic effect is better than the therapeutical effects. |
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