周继,李玉白,唐明德.金雀异黄素对大鼠骨代谢的影响.[J].中南医学科学杂志.,2005,(4):508-510.
金雀异黄素对大鼠骨代谢的影响
Influence of Genistein on Rat Biochemical Indexs of Bone
  修订日期:2005-07-20
DOI:
中文关键词:  金雀异黄素  骨代谢  碱性磷酸酶  抗酒石酸酸性磷酸酶  骨钙素  雌二醇
英文关键词:genistein,bone minetal,AKP,ACP,BGP,E_2
基金项目:
周继  李玉白  唐明德
[1]湖南环境生物职业技术学院医学部,湖南衡阳421001 [2]中南大学公共卫生学院,湖南衡阳421001
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中文摘要:
      目的 探讨金雀异黄素对大鼠骨代谢的影响。方法 取SD大鼠32只,随机分成4组,灌胃给药4周,测体重、血清碱性磷酸酶(AKP)、抗酒石酸酸性磷酸酶(ACP)活性和骨钙素(BGP)、雌二醇(E2)水平。结果 金雀异黄素40mg/kg可以增加大鼠体重、AKP活性和骨钙素水平;金雀异黄素20、30mg/kg对大鼠体重及AKP、ACP活性无明显影响。结论 金雀异黄素对骨代谢有一定的调节作用。
英文摘要:
      Objective To explore the influence of gemistein on rat biochemical indexs of bone.Methods SD rats were divided into four groups at ramdom and given different doses of genistein for one month.Serum alkaline phosphatase(AKP),osteocalcin(BGP),and tartrate-resistant acid phosphatase(ACP),estradiol(E_2),were determined by kits.Results Genistein could affect biochemical indexs of bone turnover.At high dose,genistein have an effection on accelerate formative of bones.Conclusion Genistein could adjust biochemical indexs of bone'metabolism and accelerate formative of bones and prevent lax of bone.
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