| 杨丝丝,凌宏艳,奉水东,胡弼.罗格列酮对胰岛素抵抗大鼠血清sICAM-1和sVCAM-1的影响.[J].中南医学科学杂志.,2005,(4):479-481. |
| 罗格列酮对胰岛素抵抗大鼠血清sICAM-1和sVCAM-1的影响 |
| Effects of Rosiglitazone on Serum sICAM - 1 and sVCAM - 1 in Rats With Insulin Resistance |
| 修订日期：2005-07-03 |
| DOI： |
| 中文关键词: 罗格列酮 胰岛素抵抗 细胞间黏附分子-1 血管细胞黏附分子-1 |
| 英文关键词:rosiglitazone,insulin resistance,intercellular adhesion molecule-1,vascular cell adhesion molecule-1 |
| 基金项目: |
| 杨丝丝 凌宏艳 奉水东 胡弼 |
| [1]南华大学生理学教研室,湖南衡阳421001 [2]南华大学流行病学教研室,湖南衡阳421001 |
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| 中文摘要: |
| 目的 观察罗格列酮对胰岛素抵抗（insulin resistant，IR）大鼠血清可溶性细胞间黏附分子-1（soluble intercellular adhesion molecule-1，slCAM-1）和可溶性血管细胞黏附分子-1（soluble vascular cell adhesion molecule-1，sVCAM-1）含量的影响。方法 将36只sD大鼠随机分成3组，即对照组：普通饲料喂养8周；胰岛素抵抗组（IR组）：高果糖饲料喂养8周；罗格列酮组：高果糖饲料喂养8周，后4周加用罗格列酮处理。8周末测定各实验组的空腹血糖、血胰岛素、血清sICAM-1和sVCAM-1的水平。结果与对照组相比，IR组血清sICAM-1和sVCAM-1水平增加；罗格列酮能显著降低IR大鼠血清sICAM-1和sVCAM-1水平。结论 罗格列酮能抑制IR大鼠黏附分子的产生，有助于防治IR所致的血管并发症。 |
| 英文摘要: |
| Objective To observe the effect of rosiglitazone on the levels of serum soluble intercellular adhesion molecule-1(sICAM-1) and soluble vascular cell adhesion molecule-1(sVCAM-1) in insulin resistant rats.Methods 36 male SpragueDawley(SD) rats were divided into 3 groups randomly: control group were fed with commom diet for 8 weeks,IR group were fed with high fructose diets for 8 weeks,rosiglitazone group were fed with high fructose diets for 8 weeks and treated with rosiglitazone after 4 weeks.At the end of 8th week,fasting blood glcose(FBG),fasting serum insulin(FSI),sICAM-1 and sVCAM-1 were measured respectively in groups.Results Compared with control group,serum sICAM-1 and sVCAM-1 levels significantly increased in IR group;After rosiglitazone treatment, serum sICAM-1 and sVCAM-1 levels remarkably reduced.Conclusion Rosiglitazone may inhibit the production of sICAM-1 and sVCAM-1,and play a role in the prevention and treatment of vascular complication led by insulin resistance. |
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