| 曹桂明,杨梅,洪海,颜鸿飞.缺氧诱导因子1α对乳腺癌生物学行为的影响.[J].中南医学科学杂志.,2005,(4):473-476. |
| 缺氧诱导因子1α对乳腺癌生物学行为的影响 |
| Impact of Hypoxia Inducible Factor 1a Expression With Biological Behavior on Breast Carcinoma |
| 修订日期：2005-08-05 |
| DOI： |
| 中文关键词: 缺氧诱导因子1α 乳腺肿瘤 生物学行为 |
| 英文关键词:hypoxia inducible factor-1a,breast turmor,biological behavior |
| 基金项目:湖南省教育厅课题(编号:04C557) |
| 曹桂明 杨梅 洪海 颜鸿飞 |
| 南华大学附属南华医院病理科,湖南衡阳421002 |
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| 中文摘要: |
| 目的 探讨缺氧诱导因子1α（HIF-1α）在乳腺癌组织中的表达状态以及其与临床病理因素之间的关系。方法 对行乳腺癌根治术后甲醛固定的石蜡包埋组织进行连续切片和HIF-1α免疫组化染色。结果 45例乳腺癌的HIF-1α阳性率为82．22％；HIF-1α表达与乳腺癌的组织类型、PR标志、ER标志、TNM分期、癌性坏死之间无相关性，但与淋巴结是否转移、炎症反应程度及病程长短之间有一定关系。结论 HIF-1α过表达与乳腺癌不良生物学行为有一定关系。 |
| 英文摘要: |
| Objective To investigate the relationship of the hypoxia inducible factor-1a(HIF-1a) with the clinical pathology in breast carcinoma.Methods Forty-five samples of breast carcinoma tissues were examined for HIF-1a expression by SABC immunohistochemical method.Results The positive expression rate of HIF-1a was 82.22%,the expression of HIF-1a was significantly correlated with lymph node metastasis,inflammatory reaction and course. Conclusion The overexpression of HIF-1a was related with poor biological behavior of breast carcinoma. |
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