| 杨胜辉,余敏君,吴移谋,胡四海,谭立志,冯敏,黄澍杰.衡阳地区淋病奈瑟菌流行株对大环内酯类药物敏感性的研究.[J].中南医学科学杂志.,2005,(3):322-325. |
| 衡阳地区淋病奈瑟菌流行株对大环内酯类药物敏感性的研究 |
| Study on the Susceptibility of Neisseria gonorrhoeae Epidemic Strains to Macrolides in Hengyang |
| 修订日期：2005-04-16 |
| DOI： |
| 中文关键词: 淋病奈瑟菌 琼脂稀释法 抗生素敏感性 最低抑菌浓度（MIC） |
| 英文关键词:Neisseria gonorrhoeae,agar dilution,antibiotic susceptibility,minimum inhibitory concentration(MIC) |
| 基金项目:湖南省科技厅基金(课题编号01SSY2008-6)，教育厅基金(4-01-JY-01C198,02C398)资助. |
| 杨胜辉 余敏君 吴移谋 胡四海 谭立志 冯敏 黄澍杰 |
| [1]南华大学医学微生物学与免疫学教研室,湖南衡阳421001 [2]衡阳市中心医院,湖南衡阳421001 |
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| 中文摘要: |
| 目的了解淋病奈瑟菌流行株对大环内酯类药物的敏感性，为淋病的防治提供实验依据。方法采用琼脂稀释法对分离出的101株淋球菌流行株进行了药物敏感性测定。结果在测定的4种大环内酯类药物中，淋球菌对阿奇霉素敏感性最高，达100％；其次为罗红霉素，为96．04％。交沙霉素耐药率最高，达36．63％；红霉素耐药率其次，为20．79％；罗红霉素耐药率仅为3．96％。结论阿奇霉素可作为衡阳地区淋病治疗的首选药物，罗红霉素可作为淋病治疗的替代性药物。淋球菌对大环内酯类药物有一定的不完全交叉耐药性。 |
| 英文摘要: |
| Objective To evaluate the antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains to macrolides in Hengyang and provide a referrence for the prevention and treatment of gonorrhea. Methods 101 gonococcal isolates obtained from 2003 to 2004 in Hengyang city , Hunan province , were tested for their susceptibilities to macrolides using agar dilution method. Results Of all these 4 macrolides, the higher susceptibilities to gonococci were azithromycin and roxithromycin, in turn , the percentages of susceptibility were 100%, 96.04% , respectively .On the other hand , the higher resistances to gonococci were josamycin, erythromycin and roxithromycin, the percentages of resistance were 36.63%, 20.79% 3.96%, respectively. Conclusion Azithromycin can be used as first-line agents to cure gonorrhea and roxithromycin used for alternative agents. Neisseria gonorrhoeae has some certain cross-resistance to macrolides. |
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