| 杨胜辉,吴移谋,余敏君,胡四海,谭立志,黄（氵厨）杰.淋球菌对7种抗菌药物敏感性的测定.[J].中南医学科学杂志.,2004,(3):290-293. |
| 淋球菌对7种抗菌药物敏感性的测定 |
| The Susceptibility of Neisseria Gonorrhoeae to Seven Antibiotic Agents |
| 修订日期：2004-03-21 |
| DOI： |
| 中文关键词: 淋病奈瑟菌 琼脂稀释法 抗生素敏感性 最小抑菌浓度（MIC） |
| 英文关键词:Neisseria gonorrhoeae,agar dilution,antibiotic susceptibility,minimum inhibitory concentration(MIC) |
| 基金项目:湖南省教育厅基金资助 (课题编号 :0 2C3 98) |
| 杨胜辉 吴移谋 余敏君 胡四海 谭立志 黄（氵厨）杰 |
| [1]南华大学医学微生物学与免疫学教研室,湖南衡阳421001 [2]广东江门市皮肤病防治所,湖南衡阳421001 |
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| 中文摘要: |
| 目的 了解江门地区淋球菌流行株对抗生素的敏感性，为淋病的防治提供试验依据。方法 采用琼脂稀释法对95株淋球菌临床分离株进行了药物敏感性测定。结果 在测定的7种抗生素中，对淋球菌敏感性较高的5种抗生素依次为阿奇霉素、罗红霉素、红霉素、头孢曲松和壮观霉素，其敏感率分别为100．0％、98．9％、98．9％、95．8％和94．7％。而淋球菌耐药性较高的2种抗生素依次为交沙霉素和头孢唑啉钠，耐药率均为8．4％。结论 阿奇霉素、头孢曲松和壮观霉素仍可作为江门地区淋病治疗的首选药物，但淋球菌对头孢曲松和壮观霉素已出现耐药株，应引起临床医师的高度警惕；罗红霉素、红霉素可作为江门地区淋病治疗的替代性药物。 |
| 英文摘要: |
| Objective To evaluate the antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains in jiangmen and to provide a referrence for the prevention and treatment of gonorrhea. Methods 95 gonococcal isolates were tested for their susceptibilities to 7 antibiotic agents using agar dilution method. Result Of all these 7 antibiotic agents , the higher susceptibilities to gonococci were azithromycin , roxithromycin , erythromycin , ceftriaxone , spectinomycin in turn , the percentages of susceptibility were 100.0% , 98.9% , 98.9% , 95.8% , 94.7% respectively .On the other hand , the higher resistances to gonococci were josamycin and cefazolin ,the percentages of resistance were all 8.4%. Conclusion Azithromycin , ceftriaxone and spectinomycin can still be used as primary agents to cure gonorrhea , but clinical doctors need to pay more attention to them , because resistant strains to ceftriaxone and spectinomycin have come into existence. Roxithromycin and erythromycin can be used alternative agents to cure gonorrhea . |
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