王力,马艳,吴成秋,陈临溪.人胃癌中端粒酶活性表达的研究.[J].中南医学科学杂志.,2000,(4):.
人胃癌中端粒酶活性表达的研究
Expression of Telomerase in Human Gastric Carcinoma
  
DOI:
中文关键词:  胃肿瘤,端粒酶,聚合酶链反应
英文关键词:gastric carcinoma,telomerase,polymerase chain reaction
基金项目:
王力  马艳  吴成秋  陈临溪
衡阳市中心医院普外科!湖南衡阳421001(王力)
,衡阳医学院附一医院妇产科(马艳)
,衡阳医学院卫生学教研室(吴成秋)
,衡阳医学院药理学教研室(陈临溪)
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中文摘要:
      目的 探讨人胃癌组织中端粒酶的活性表达。方法 采用端粒重复序列扩增法 (temolericrepeatamplificationprotocol,TRAP)检测 4 2例原发性胃癌及相应的癌旁组织中端粒酶活性。结果 在 4 2例胃癌中 ,有 35例端粒酶呈阳性 ,而癌旁组织中仅有 2例阳性。结论 端粒酶激活与胃癌的发生有关 ,并可能成为诊断胃癌的肿瘤标记物
英文摘要:
      Objective:To investigate telomerase expression in human gastric carcinoma.Method:Telomerase activity in 42 primary gastric carcinomas and tumor adjacent tissues was detected by telomeric repeat complification protocol(TRAP).Result:35 out of 42 (83.33%) tumor samples exhibited telomerase activity.However,telomerase activity in the tumor-adjacent tissues was detected only in 2 of 42 specimens(4.76%).Conclusion:Telomerase expression might contribute to the generation of gastric carcinoma and could be used as the tumor marker of gastric carcinoma.
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