| 戴爱国,李柏完,陈红芳,范咏梅.慢性阻塞性肺疾病患者呼出气NO含量的变化及吸入NO对其肺功能的影响.[J].中南医学科学杂志.,2000,(2):. |
| 慢性阻塞性肺疾病患者呼出气NO含量的变化及吸入NO对其肺功能的影响 |
| The Changes in Exhaled Endogenous NO of Patients with Chronic Obstructive Pulmonary Disease and the Effects of Inhaled NO on Pulmonary Function |
| |
| DOI： |
| 中文关键词: 肺疾病,阻塞性,一氧化氮,呼出气,肺功能,吸入疗法 |
| 英文关键词:lung disease, obstructive,nitric oxide,exhaled gas,pulmonary function,inhalationement in radiobiology, the respective molecular mechanisms underlying cell kinetics alteration and DNA damage repair is being revealed gradually and takes |
| 基金项目: |
| 戴爱国 李柏完 陈红芳 范咏梅 |
衡阳医学院第三附属医院!湖南衡阳421900(戴爱国，李柏完)
，衡阳医学院第一附属医院(陈红芳，范咏梅)
|
| 摘要点击次数: 922 |
| 全文下载次数: 0 |
| 中文摘要: |
| 为探讨一氧化氮 (NO)在慢性阻塞性肺疾病 (COPD)发病中的作用及吸入NO对COPD肺功能的影响 ,本研究检测了COPD患者鼻、口呼出气中NO的含量及吸入不同浓度 (10～ 80ppm)NO时肺功能和血气指标。结果表明 :COPD患者鼻、口呼出气NO含量均明显低于对照组 (P <0 .0 1) ,且COPD和对照组口呼出气NO含量低于鼻呼出气 (P <0 .0 1) ;吸入 2 0～ 80ppmNO能明显改善COPD患者部分肺通气功能指标(FEV1、FEV1/FVC、FEV1%、PEF) ,且呈效量依赖关系 ,但对肺容量和肺弥散功能指标无明显影响 ;吸入NO后COPD患者PaCO2 增加 ,但对PaCO2 和高铁血红蛋白无明显影响。提示NO合成减少可能介导了COPD的发病 ,吸入一定浓度的NO可改善COPD患者肺通气功能和PaO2 |
| 英文摘要: |
| WT5BZ]To investigate the role of nitric oxide(NO) in pathogenesis of chronic obstructive pulmonary disease(COPD) and the effects of inhaled NO on pulmonary function of patients with COPD. In this study, exhaled NO was continuously measured by chemiluminescence technique during normal tidal breathing through the nose or mouth,and the pulmonary function index were monitored after inhalation of 10-80 ppm NO in 18 patients with COPD and 12 control subjects.The results showed that the nose and mouth exhaled NO levels in COPD were significantly lower than those in control group (P<0.01),the mouth exhaled NO level was lower than the nose in both COPD and control groups (P<0.01).Inhalation of 20-80 ppm NO could markedly increase some pulmonary ventilation function index (e.g.FEV 1/FVC,FEV 1%, PEF) with a dose-dependant relationship as well as could increase PaO 2,but could not affect the index of lung volume,lung diffusion function,PaCO 2 and plasma methemoglobin level in COPD patients.It is suggested that a decrease of endogenous NO may regulate pathogenesis of COPD, and inhaled low dose NO can improve pulmonary function and PaO 2 of patients with COPD. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|