| 周卫红,周艺,万艳平,杨露青,陈章国.乙型肝炎病毒基因疫苗诱导抗体的产生.[J].中南医学科学杂志.,1999,(4):. |
| 乙型肝炎病毒基因疫苗诱导抗体的产生 |
| Antibody Induced by Hepatitis B Virus Gene Vaccine |
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| DOI： |
| 中文关键词: 乙型肝炎病毒,基因疫苗,抗体 |
| 英文关键词:hepatitis B virus,gene vaccine,antibody |
| 基金项目:湖南省科委资助课题 |
| 周卫红 周艺 万艳平 杨露青 陈章国 |
| 衡阳医学院病原检测教研室!衡阳，421001，衡阳医学院病原检测教研室!衡阳，421001，衡阳医学院病原检测教研室!衡阳，421001，衡阳医学院病原检测教研室!衡阳，421001，衡阳医学院病原检测教研室!衡阳，421001 |
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| 中文摘要: |
| 乙型肝炎病毒(HBV) 基因疫苗可打破人群对HBV 表面抗原(HBsAg) 疫苗免疫无应答或低应答而产生保护性抗体,并有可能成为治疗HBV 持续性感染的特异性基因治疗剂。我们用构建的MS2 - preS表达质粒pMIP、IL- 2 - preS原核表达质粒pIIP、IL- 2- preS真核表达质粒pCWIIP分别经小鼠尾部皮下接种。实验结果显示3 种质粒均能诱导小鼠产生抗- preS抗体,且pIIP与pCWIIP产生抗体量高于pMIP(SAS统计分析,P< 0 .01) ,这说明IL- 2 - preS基因疫苗在体内可能有多种生物学功能,同时产生协同作用。pCWIIP产生抗体量略高于pIIP(SAS统计分析,p > 0.05) |
| 英文摘要: |
| The gen vaccine of hepatitis B virus(HBV)is able to help body overcoming iune tolerance and low iune response to HBsAg and induces body to produce proventive antibody.It may be a specific gene therapcutic agent for HBV persistent infection. Balb/c mice were subcutaneously iunized with the plasmid pCWIIP,pIIP,pMIP,pCIIL 2 and the results showed that the best effect was pCWIIP,the better was pIIP,the last was pMIP.It was conviced that the gene vaccine of IL 2preS had multi bioactivities. There was a cooperative function between IL 2 and preS. |
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