| 李恩华,李红敏,朱超美,龙治峰.M-CSF及其受体在肿瘤细胞系中的表达.[J].中南医学科学杂志.,1999,(1):. |
| M-CSF及其受体在肿瘤细胞系中的表达 |
| Expression of Macrophage Colony Stimulating Factor (M CSF) and M CSF receptor in Tumor Cell Lines |
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| DOI： |
| 中文关键词: M-CSF M-CSF受体 基因表达 |
| 英文关键词:M CSF,c fos,gene expression |
| 基金项目: |
| 李恩华 李红敏 朱超美 龙治峰 |
| 衡阳医学院生理学教研室 |
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| 中文摘要: |
| 本文使用免疫酶标技术 ＡＢＣ法研究了ＨＬ ６０，ＭＧＣ ８０和ＭＣＦ ７三个细胞系中Ｍ ＣＳＦ及其受体的表达，结果表明，在ＨＬ ６０和ＭＣＦ ７细胞系中，Ｍ ＣＳＦ和Ｍ ＣＳＦ受体在细胞膜、细胞质和细胞核中均有表达，而ＭＧＣ ８０细胞系的Ｍ ＣＳＦ和Ｍ ＣＳＦ受体只在细胞膜和细胞质中出现阳性表达，而细胞核未见阳性表达。Ｍ ＣＳＦ和Ｍ ＣＳＦ受体在上述细胞系中，其表达可能暗示上述细胞系存在自分泌现象。此外，本文还讨论了Ｍ ＣＳＦ及其受体的核内分布的可能机制及其意义。 |
| 英文摘要: |
| Expression of macrophage colony stimulating factor(M CSF) and M CSF receptor in MGC 80,MCF 7 and HL 60 cell line was studied by immunochemistry technique ABC method.Expression of M CSF and M CSF receptor was detected in the cell membrane,cytoplasm,and nucleus of MCF 7 and HL 60 cell line,and only in the cell membrane,cytoplasm of MGC 80 cell line.These results indecated co expression of M CSF and M CSF receptor in the cell lines,which suggested that there could be and autocrine loop in cell lines above.In addition,the possible mechanism and significance of nuclear M CSF receptor were discussed. |
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