| 胡宝春,曾明新,李晓清,阳学风.绞股蓝总皂甙对原代培养大鼠肝细胞四氯化碳损伤的影响.[J].中南医学科学杂志.,1996,(4):. |
| 绞股蓝总皂甙对原代培养大鼠肝细胞四氯化碳损伤的影响 |
| The Effect of Gypenosides on Carbon Tetrachlorside Induced Injury in Primary Cultured Rat Hepatocytes |
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| DOI： |
| 中文关键词: 绞股蓝总皂甙，四氯化碳，大鼠，肝细胞损伤，脂质过氧化 |
| 英文关键词:gypenosides,carbon tetrachloride,hepatocellular injury,lipid peroxidation,rat |
| 基金项目: |
| 胡宝春 曾明新 李晓清 阳学风 |
| 衡阳医学院第二附属医院消化内科，广东省武警总队医院消化内科，珠海市拱北医院内科 |
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| 中文摘要: |
| 采用四氯化碳（ＣＣｌ_４）制成原代培养大鼠肝细胞损伤模型，观察了绞股蓝总皂甙（ＧＰＳ）对肝细胞损伤的保护作用。结果表明，预先用ＧＰＳ处理肝细胞１ｈｒ，可明显减轻ＣＣｌ_４引起的肝细胞ＤＮＡ合成速率降低，减少肝细胞ＡＬＴ逸出，抑制培养上清液中ＭＤＡ含量的升高和ＳＯＤ／ＭＤＡ比值的缩小，并与ＧＰＳ浓度呈依赖关系。提示ＧＰＳ能减轻ＣＣＬ_４能减轻ＣＣｌ_４对离体培养的大鼠肝细胞损伤，保护肝细胞ＤＮＡ合成，其作用机理与抗脂质过氧化有关。 |
| 英文摘要: |
| This in vitro study on the effect of Gypenosides(GPS) on carbon tetrachloride(CCl_4) induced injury in primary cultured rat hepatocytes showed that the decrease of their DNA synthesis rate and ALT leakage caused by CCl_4 were inhibited dose dependently when hepatocytes were pretreated with GPS,and the concentration of MDA was less and SOD/MDA more,in their medium,than that of injured control.It suggests the protection,which is associated with anti-lipid peroxidation,of GPS on CCl_4 induced hepatocellular injury in vitro. |
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