| 王宗保,张元凯,李一琴.黄曲霉毒素B_1诱发鲫鱼肝细胞癌的实验研究.[J].中南医学科学杂志.,1996,(1):. |
| 黄曲霉毒素B_1诱发鲫鱼肝细胞癌的实验研究 |
| Hepatocellular Carcinoma of Carassius Auratus L. induced by Aflatoxin B1 |
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| DOI： |
| 中文关键词: 肝肿瘤 黄曲霉毒素B_1：鲫鱼 |
| 英文关键词:liver neoplasm,aflatoxin B1,carassius auratis L, |
| 基金项目: |
| 王宗保 张元凯 李一琴 |
| 衡阳医学院实验动物部，衡阳医学院肿瘤研究所 |
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| 中文摘要: |
| 本文报道用含５－３０ｐｐｂ黄曲霉毒素Ｂ１（ＡＦＢ１）饲料连续喂养鲫鱼（ＣａｒａｓｓｉｕｓａｕｒａｔｕｓＬ）诱发鱼肝癌，２４周后处死，实验组１６尾鲫鱼中有５尾出现原发性肝细胞癌，肝癌诱发率为３１．２％。对照组鲫鱼均未见肝脏组织癌变。ＡＦＢ１诱发的鱼肝癌为灰白色肿块，癌细胞异型性明显，围绕血管排列成巢状或实质团块状。 |
| 英文摘要: |
| Carassius auratis L. were fed persistently with a ration containing aflatoxin B1 at concentration ranging 5ppb to 30 ppb.After 24 weeks,all the test fish were killed.and 5 of 16 fish were noted to have primary hepatocellular carcinoma. The induced rate of liver cancer was 31.2%.The control fish was negative to cancer.The fish's liver cancer induced by aflatoxin Bl was greywhite Swollen block. The heteromorphism of cancer cells was quite clear.Cells ranged around vessels at nest and block. |
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