谭敏,周秀田,金山,高学硕,田竟生.流式细胞术在甲状腺乳头状良恶性肿瘤诊断及预后中的应用.[J].中南医学科学杂志.,1996,(1):.
流式细胞术在甲状腺乳头状良恶性肿瘤诊断及预后中的应用
Application of FCM in prognosis and diagnosis for human thyroid papillary tumor
  
DOI:
中文关键词:  甲状腺肿瘤  流式细胞技术  DNA含量
英文关键词:FCM,thyroid neoplasm,DNA content,
基金项目:
谭敏  周秀田  金山  高学硕  田竟生
衡阳医学院肿瘤研究所,北京市肿瘤防治研究所
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中文摘要:
      用流式细胞仪对37例石蜡包埋甲状腺乳头状肿瘤(15例甲状腺乳头状瘤,22例甲状腺乳头状癌)标本进行了DNA含量及细胞增殖活力程度的测量。结果显示:甲状腺乳头状癌的非整倍体率明显高于甲状腺乳头状瘤;甲状腺乳头状癌的增殖指数(PI)及S期指数明显大于甲状腺乳头状瘤,即使为二倍体的乳头状癌其直方图上仍表现出S期升高。提示:DNA非整倍体的出现,PI和S期指数的增高是甲状腺乳头状癌诊断和预后评价的主要参考依据。
英文摘要:
      DNA content and cell proliferation were measured by flow cytometry on paraffin-embedded tissue from 37 human papillary tumors of the thyroid(15 papillary adenoma and 22 papillary carcinoma).The Aneuploid and S-phase fraction in papillary carcinomas were higher than those in papillary adenomas(P<0.01).Our results indicated that DNA index and cell kinetic parameters have an important value for human thyroid papillary carcinoma diagnosis.
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