| 杨和平,杨爱莲,王小平,陈颜芳.L－精氨酸抗家兔动脉粥样硬化内皮损伤.[J].中南医学科学杂志.,1995,(3):. |
| L－精氨酸抗家兔动脉粥样硬化内皮损伤 |
| Influence of L-Arginine on the Endothelium Lesion in Atherosclerotic Plaques in Rabbits. |
| |
| DOI： |
| 中文关键词: L－精氨酸，一氧化氮，内皮细胞，动脉粥样硬化 |
| 英文关键词:L-arginine,Nitric oxide,Endothelium,Atherosclerosis |
| 基金项目:湖南省卫生厅重大攻关项目 |
| 杨和平 杨爱莲 王小平 陈颜芳 |
| 衡阳医学院分子生物学研究中心，北京医科大学第三医院 |
| 摘要点击次数: 806 |
| 全文下载次数: 2 |
| 中文摘要: |
| 将新西兰兔分成三组：正常组、高胆固醇组、高胆固醇加Ｌ－精氨酸组。分别喂养４周和８周。扫描电镜下观察到：高胆固醇组与高胆固醇加Ｌ－精氨酸组相比，内皮细胞排列不规则，细胞间隙银染较粗，内膜损伤和增生明显。说明补充Ｌ－精氨酸可减轻内膜损伤。 |
| 英文摘要: |
| ew Zealand white rabbits were divided at random into three groups which were,fed a normal chow(Control) and a high-cholesterol diet(HCD)a high cholesterol diet suplemented with L-arginine(HCD-Arg)for 4 or 8weeks respectively. In the high-cholesterol diet group (vs HCD-Arg group),scanning electron microyraphs of rabbit aortic arteries stained with silver nitrate showed that endothelium cells had irregular sizes and lacked the typical alignment in the direction of blood flow.Permeability of endothelium cells of atherosclerotic plaques was increased in HCD group (vs HCD-Arg group). Meanwhile, L-arginine could partly inhibit the development of atherosclerotic plaques. These data suggest that hypercholesterolemia enhances the endothelium lesion; this effect is affenuated by dietary L-arginine. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|