| 匡希文,雷风生,朱建思,董琳,李一琴,甘润良,李小玲,孙去病.大肠癌及慢性溃疡性结肠炎的免疫组化研究.[J].中南医学科学杂志.,1992,(4):. |
| 大肠癌及慢性溃疡性结肠炎的免疫组化研究 |
| Immnohistochemical Study of Large Bowel Carcinoma and Chronic Ulcerative Colitis |
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| DOI： |
| 中文关键词: 结肠炎,溃疡性,肠肿瘤,单克隆抗体 |
| 英文关键词:colitis,ulcerative,intestinal neoplasm,monoclonal antibody |
| 基金项目: |
| 匡希文 雷风生 朱建思 董琳 李一琴 甘润良 李小玲 孙去病 |
| 衡阳医学院肿瘤研究所，衡阳市中心医院，衡阳医学院肿瘤研究所，衡阳医学院肿瘤研究所，衡阳医学院肿瘤研究所，衡阳医学院肿瘤研究所，湖南医科大学肿瘤研究所，湖南医科大学肿瘤研究所 |
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| 中文摘要: |
| 本文应用大肠癌单克隆抗体Hb_3对20例大肠癌、60例慢性溃疡性结肠炎(CUC)、12例正常成人大肠粘膜和12例胎儿大肠粘膜进行了免疫组织化学检查。结果表明,大肠癌HL_3反应阳性率是80％,CUC阳性率为41.7%,正常大肠粘膜阳性率是8.3%,胎儿大肠粘膜全为阳性。而且,在CUC病例中,直肠部位CUC的Hb_3反应阳性率明显高于直肠以上部位者,这与大肠癌好发于直肠的事实相符。作者认为,慢性溃疡性结肠炎表达肿瘤相关抗原是先于病理形态改变之前的极早期生化异常,进一步支持CUC是大肠癌的癌前期疾病,这对于CUC的追踪观察以及探讨CUC与大肠癌发生的关系有一定意义。 |
| 英文摘要: |
| Monoclonal antibody Hb3 against large bowel carcinoma,was used to study 20 large bowel carcinomas,60 chronic ulcerative colitises(CUC),12 normal large bow- el mucosas and 12 fetal large bowel mucosas by immunohistochemical method.The results showed that the positive rate of Hb3 binding to large bowel carcinoma, CUC,normal large bowel mucosa and fetal large bowel mucosa were 80%,41.7%, 8.3% and 100% respectively.In addition,the positive rate of Hb3 binding to CUC in rectal site was higher than those in colonic site,which agreed with the fact that large bowel carcinomas were easily found in the rectum.Authors considered that the expression of tumor associated antigen in CUC is a very early biochemical ab- normality before morphopathological changes.The present results further support that chronic ulcerative colitis is a precancerous diseaase of large bowel carcinoma. Therefore,Hb3 immunohistochemical investigation was benificial to follow up of CUC and study of the relationship between CUC and large bowel carcinoma. |
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