| 廖端芳,余麟,陈剑雄,应建华.一种观察血管内皮损伤与自由基关系的新方法——Ⅱ、内皮扫描电镜观察.[J].中南医学科学杂志.,1992,(4):. |
| 一种观察血管内皮损伤与自由基关系的新方法——Ⅱ、内皮扫描电镜观察 |
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| DOI： |
| 中文关键词: 自由基,内皮衍生松驰因子,内皮损伤,家兔 |
| 英文关键词:free radicals,endothelium-derived relaxing factor,endohelium injury,rabbit |
| 基金项目: |
| 廖端芳 余麟 陈剑雄 应建华 |
| 衡阳医学院药理教研室，衡阳医学院药理教研室，衡阳医学院药理教研室，衡阳医学院电镜室 |
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| 中文摘要: |
| 本研究用离体兔胸主动脉淋浴灌流系统电解Krebs液损伤血管内皮模型,观察了自由基对血管内皮的影响。结果发现,电解性自由基在损伤血管内皮释放EDRF能力的同时,内皮细胞完整性遭破坏,细胞膜凹陷,细胞间隙增宽及部分区域内皮细胞脱落。 |
| 英文摘要: |
| We studied effects of OFR on morphology of endothelium with a new method (we reported previously)of combining superfusion cascade system with electrolyzed physiological solution.The SEM of the luminal surface of donor vessels perfused with electrolysate by 5 mA for 1 min showed loss of endothelial integrity,widening or intercellular spaces and pitting of the cell membrane.Crateriform and erosc ap- pearance were also observed in some areas.It was concluded that the new method is also practical for the study of the correlation between morphology change of en- dothelium and OFR. |
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