| 阮琬玉,袁杰,欧和生.高血压病及其并发症患者VWF、t—PA及PAI活性的临床研究.[J].中南医学科学杂志.,1992,(1):. |
| 高血压病及其并发症患者VWF、t—PA及PAI活性的临床研究 |
| The Clinical Study on VWF, tPA and PAI in Patients with Hypertension |
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| DOI： |
| 中文关键词: 高血压病,VWF,组织型纤溶酶原激活物,纤溶酶原激活物抑制剂 |
| 英文关键词: |
| 基金项目: |
| 阮琬玉 袁杰 欧和生 |
| 衡阳医学院第二附属医院内科，衡阳医学院第二附属医院内科，衡阳医学院心血管病研究所 |
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| 中文摘要: |
| 本文以酶联免疫吸附试验定量测定高血压病及其并发症患者血浆VWF含量、以发色底物比色法测定患者血浆的t—PA和PAI活性。结果表明:高血压病患者血浆VWF量增高、t—PA活性下降、PAI活性增高;有并发症的高血压患者的上述指标变化比单纯高血压病患者更显著。本资料提示高血压病患者血液促凝活性增强,纤溶活性减弱,有并发症者变化更加明显。这将有助于探讨高血压病的发病机理,为临床上防治高血压病及其并发病提供临床资料和理论依据。 |
| 英文摘要: |
| The plasma VWF concentration, tPA and PAI activity were examined in patients with essential hypertension. The results showed that VWF increased, tPA activity decreased and PAI activity increased in patients. These changes were more severe in patients with complications than those without complications. Our data suggested that increasing procoagulant activity and decreasing fibrinolytic activity occured in patients with essential hypertension, especially in patients with complications. This study helps explore the mechanism of hypertension, and provides clinic data and theoretic supports for therapy of the diseases. |
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