| 黄宗之,陈辉.糖尿病人体内胰岛素抗体对胰岛素药效学的影响.[J].中南医学科学杂志.,1991,(2):. |
| 糖尿病人体内胰岛素抗体对胰岛素药效学的影响 |
| EFFECT OF INSULIN ANTIBODY ON INSULIN PHARMACODYNAMICS IN DIABETES |
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| DOI： |
| 中文关键词: 胰岛素抗体,胰岛素药效动力学 |
| 英文关键词:Insulin Antibody,Insulin Pharmacodynamics,Diabetes |
| 基金项目: |
| 黄宗之 陈辉 |
| 衡阳医学院内分泌研究室，宁波市医学科学研究所 |
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| 中文摘要: |
| 作者对10例胰岛素抗体(IAb)阴性病人和8例 IAb 阳性病人作了胰岛素药效学分析,结果表明,IAb 阳性组胰岛素累积效应和峰效应及解离常数均比 IAb 阴性组大,提示 IAb 延长了外源性胰岛素作用时间,加大胰岛素的峰作用并影响胰岛素与受体结合。 |
| 英文摘要: |
| To investigate the effects of insulin antibody(IAb)on insulin pharmacodynamics,10 IAB-negative and 8 IAb-positive patients were monitored for 71/2 hours after subcutaneous injection of regular insulin(14U).The results show:AUCE,peak effect,and dissociation constant(K) in IAb-positive patients were larger than that in IAb-na- gative patients.These data suggest that IAb(1)prolongs the action of injected insulin;(2)increases the peak effect of insulin;(3) affects insulin binding to insulin receptor. |
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