| 杨和平,杨永宗,涂玉林.动脉粥样硬化形成和消退的形态学研究.[J].中南医学科学杂志.,1990,(3):. |
| 动脉粥样硬化形成和消退的形态学研究 |
| Studies on Pathogenesis in Formation and Regression of Atherosclerosis |
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| DOI： |
| 中文关键词: 内皮细胞,平滑肌细胞,单核细胞,动脉粥样硬化,形态结构 |
| 英文关键词:SMCs,EC,macrophage,AS,pathogenesis |
| 基金项目:湖南省卫生厅青年科技基金，国家自然科学基金资助 |
| 杨和平 杨永宗 涂玉林 |
| 衡阳医学院心血管病研究所，衡阳医学院心血管病研究所，衡阳医学院心血管病研究所 |
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| 中文摘要: |
| 本文报告动脉粥样硬化(AS)形成和消退研究的部分工作。在复制AS形成和消退模型的基础上,研究了AS形成和消退中的内皮细胞、平滑肌细胞和单核细胞的改变。 |
| 英文摘要: |
| Studies on the pathogenesis of atherosclerosis (AS) were reviewed in our department. During the formation of AS, the sarcoplasm of the medial and intimal smooth muscle cells ( SMCs ) were filled with Golgi complex, mitochondrion and rough endoplasmic reticulum. The SMCs might be in synthetics state and in relation to hyperplasm and transfer. The lines of argentation and surface area of EC were increased,which might be relationship with the increase of the permeability of EC and the initiation and develop ment of AS. EC were filled with Golgi complex, mitochondrion and rough endoplasmic reticulum, which related with the increase of EC activity.There were a lot of foam cells adhesion and aggregation in the endothelium, which might relate with formation of fatty streaks.
During the regression of AS, the ultrastructure of SMCs and EC was almost normal. The SMCs might be in contractile state. The metabolic activlty of EC might be lower than one of EC of AS group. The macrophages inbibed cholesterol and cholesterol ester, which played a important in cleaning cholesterol and cholesterol ester. |
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