| 黄宗之,袁乃文,黄咏齐,高寅春.胰岛素降糖反应延迟机理的初步探讨.[J].中南医学科学杂志.,1987,(4):. |
| 胰岛素降糖反应延迟机理的初步探讨 |
| MECHANISM OF GLUCOSE-DECREASING DELAY OF INSULIN |
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| DOI： |
| 中文关键词: 胰岛素最大作用时间,血糖(BG),游离胰岛素(FI),胰高糖素(G),皮质醇(F),生长激素(GH),胰岛素依赖性糖尿病(IDDM) |
| 英文关键词:maximal insulin action (MIA) blood glucose (BG) free insulin(FI) glucagon(G) cortisol(Co) glowth hormone (GH) |
| 基金项目: |
| 黄宗之 袁乃文 黄咏齐 高寅春 |
| 衡阳医学院内分泌研究室，蚌埠医学院内分泌研究室，蚌埠医学院内分泌研究室，上海市第一人民医院内科 |
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| 中文摘要: |
| 本文对10例IDDM病人皮下注射胰岛素后作了7.5小时动态观察,测定了BG、FI、G、F和GH。基础BG高者,胰岛素最大降糖作用延迟,降糖过程中,GH的升糖效应最敏感,G和F升高与血糖回升时间相一致,在BG高者,呈延迟反应。这种延迟反应可能是由于血糖高,使到达刺激后二种升糖激素分泌阈值所需的时间延长有关。 |
| 英文摘要: |
| Ten cases with insulin-dependet diabetes mellitus(IDDM)were monitored for 7.5 hours following subcutaneous injection of regular insulin.The free insulin,glucagon, cortisol,and growth hormone were measured.In these cases with severe hyperglycemia, Tne maximal action of insulin was delayed. The secretion of glucagon and cortisol in response to glucosedecreasing was put off. The delay can be that severe hyperglycemic state needs longer time to bring about these hormone secreting markly. |
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