| 唐耀华,张蜀中,曾彩旋,肖继皋.5—氟脲嘧啶并用大剂量青霉素引起急性粒细胞缺乏症和贫血一例报告(附动物实验研究).[J].中南医学科学杂志.,1985,(3):. |
| 5—氟脲嘧啶并用大剂量青霉素引起急性粒细胞缺乏症和贫血一例报告(附动物实验研究) |
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| DOI： |
| 中文关键词: 急性粒细胞缺乏症,贫血,青霉素,5—氟脲嘧啶,病理损害,并发症 |
| 英文关键词:Acute agranulocytosis Anemia Penicillin 5-FU Pathological impairment Complication |
| 基金项目: |
| 唐耀华 张蜀中 曾彩旋 肖继皋 |
| 衡阳医学院附属一医院肿瘤科，南京医学院药理室 |
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| 中文摘要: |
| 本文报导一例5—FU并用大剂量青霉素治疗乳癌、引起急性粒细胞缺乏症和贫血。实验研究提示单纯大剂量青霉素对免造血系统有损害。如再并用5—FU不仅可加剧肝肾组织病理损害且有可能诱发严重并发症——粒细胞缺乏症和贫血。 |
| 英文摘要: |
| A case of breast cancer patient developed agranulocytosis and anemia after large doses of penicillin in combination with 5-FU is reported. Experimental studies showed that single use of penicillin was harmful for the hematopoietic system of rabbits. If large doses of penicillin were combined with 5-FU, not only liver and kidney functions would be seriously impaired, severe complications such as agranulocytosis and anemia would ensue. |
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