| 方有传,申天喜.重型颅脑损伤患者颅内压与神经元特异性烯醇化酶、C-反应蛋白及D-二聚体水平变化关系研究.[J].中南医学科学杂志.,2018,(4):408-410. |
| 重型颅脑损伤患者颅内压与神经元特异性烯醇化酶、C-反应蛋白及D-二聚体水平变化关系研究 |
| Study on the relationship between intracranial pressure and NSE, CRP and D-dimer in patients with severe craniocerebral injury |
| 投稿时间：2018-01-03 修订日期：2018-05-30 |
| DOI：10.15972/j.cnki.43-1509/r.2018.04.020 |
| 中文关键词: 颅脑损伤 颅内压 神经元特异性烯醇化酶 C-反应蛋白 D-二聚体 |
| 英文关键词:craniocerebral injury intracranial pressure NSE CRP D-dimer |
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| 中文摘要: |
| 探讨重型颅脑损伤患者颅内压改变与神经元特异性烯醇化酶、C-反应蛋白和D-二聚体的关系。 采用电化学发光免疫分析法检测两组血清神经元特异性烯醇化酶,免疫比浊法检测C-反应蛋白和D-二聚体水平。 重型颅脑损伤患者神经元特异性烯醇化酶、C-反应蛋白和D-二聚体指标的水平均显著高于健康者,监测颅内压重度增高组患者的神经元特异性烯醇化酶、C-反应蛋白和D-二聚体水平均显著高于中度增高组。结果说明,重型颅脑损伤患者颅内压改变与患者血清中神经元特异性烯醇化酶、C-反应蛋白和D-二聚体指标水平存在明显的正相关性。 |
| 英文摘要: |
| To investigate the relationship between the intracranial pressure and neuron specific enolase(NSE), C-reactive protein(CRP) and D-dimer levels in patients with severe craniocerebral injury. Two groups of serum NSE were detected by electrochemiluminescence immunoassay, and immuno turbidimetry was used to detect the level of NSE,CRP and D-dimerr. The levels of, CRP protein and D-dimerr were significantly higher in patients with severe craniocerebral injury than in healthy subjects,the levels of NSE, CRP and D-dimerr in patients with severe intracranial hypertension were significantly higher than those in the moderate increase group. There is a positive correlation between intracranial pressure and serum levels of neuron specific enolase, C- reactive protein and D- two dimer in patients with severe craniocerebral injury. |
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